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pentobarbital will reduce the extent or outcome of cariprazine by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lessen the level or effect of oliceridine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. If coadministration with a CYP3A4 inducer is important, consider escalating oliceridine do